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For over 60 years, we thought metformin worked mainly through the liver and gut. But new research suggests the brain may play a major role too. This study identified a specific brain pathway (Rap1 in the hypothalamus) that appears critical to metformin’s glucose-lowering effects, potentially reshaping how we understand one of the world’s most prescribed diabetes medications. Source: Sci. Adv. 2025;11:eadu3700
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STARTING METFORMIN: 3 THINGS TO KNOW If you have just been prescribed metformin, here are three things I would explain at the pharmacy counter. 1. YOU MAY NOT FEEL IT WORKING Metformin helps lower the glucose—sugar—in your blood. It reduces some of the glucose released by your liver and helps your body respond better to insulin. You may feel exactly the same, so do not judge it by symptoms alone. Your blood glucose results and HbA1c—a blood test showing your average glucose over the previous two
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